Aripiprazole maintenance increases smoked cocaine self-administration in humans
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چکیده
منابع مشابه
Enadoline and Butorphanol: Evaluation of -Agonists on Cocaine Pharmacodynamics and Cocaine Self-Administration in Humans
Preclinical studies have demonstrated that -opioid agonists can attenuate the neurochemical and behavioral effects of cocaine that are related to its reinforcing efficacy, suggesting that -agonists may serve as pharmacotherapies for cocaine dependence. This 8-week inpatient study examined the ability of enadoline, a selective and high-efficacy -agonist, and butorphanol, a mixed agonist with int...
متن کاملEnadoline and butorphanol: evaluation of kappa-agonists on cocaine pharmacodynamics and cocaine self-administration in humans.
Preclinical studies have demonstrated that kappa-opioid agonists can attenuate the neurochemical and behavioral effects of cocaine that are related to its reinforcing efficacy, suggesting that kappa-agonists may serve as pharmacotherapies for cocaine dependence. This 8-week inpatient study examined the ability of enadoline, a selective and high-efficacy kappa-agonist, and butorphanol, a mixed a...
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Drug addiction is characterized by compulsive drug-taking behaviors and a high propensity to relapse following drug cessation. Drug craving and seeking can increase during a period of abstinence, but this phenomenon is not observed in drug-induced reinstatement models. To investigate the effect of withdrawal on cocaine relapse, rats were exposed to extended-access cocaine self-administration an...
متن کاملSmoked cocaine in socially-depressed areas
BACKGROUND The main objectives of this study are to describe the smoked cocaine user's profile in socially-depressed areas and their needs from a harm-reduction perspective, to investigate their use of smoking crack and compare the acute effects between injecting and smoking consumption. METHODS The study took place in SAPS, Barcelona, Spain. Two focus group sessions were undertaken with a to...
متن کاملAccumbal neural responses during the initiation and maintenance of intravenous cocaine self-administration.
During a chronic extracellular recording session, animals with a history of cocaine self-administration were allowed to initiate drug seeking under drug-free conditions. Later, in the same recording session, animals engaged in intravenous cocaine self-administration. During the drug-free period, 31% of 70 accumbal neurons showed a significant increase in average firing rate in association with ...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2011
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-011-2231-6